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Everybody has different opinions on what kind of shots to give and when to give them. I can only tell you what works for us. We normally take our puppies away from the mama at 6 weeks of age. I have done 5 and 7 but normally 6. As soon as they are off their mama we give them a 5-way, 2 weeks later a 5-way and 2 weeks later another one. When they are 12 weeks old we give them a shot with Lepto in it. You can use a 7-way or a straight Lepto shot. At 16 weeks give them another with Lepto. At 6 months they get a Rabies shot. That's what we do and it works for us. We also give them a kennel jet in their nose for kennel cough in between the 1st and 2nd shot. I know that sounds like a lot and expensive but it works for us and the pups get what they need.